Selected Publications

  1. Jason Li*, Benjamin G. Clark, Parmiss Khosravi, Colin Cotter, Jia Y. Liang, Susan R. Ling, Yuyan Su, Kent J. Qi, Flavia Codreanu, Ethan D’Orio, Ivy Tianqin Tan, Julia E. Green, Katarzyna Murawska, Aaron Lopes, Benjamin N. Muller, Alison M. Hayward, Niora Fabian, Andrew Pettinari, Kailyn Schmidt, Benedict Laidlaw, Maria Platero, Ashley Guevara, Joshua D. Bernstock, Stephanie Y. Owyang, Peter R. Chai, Robert Langer, Giovanni Traverso*. Monolithic Shape-Shifting Absorbable Implants for Long-Term Contraception. (BIORXIV/2025/654764, under review: Sci. Trans. Med.)
  2. Jason Li, Jia Y. Liang, Anika Meng, Sejun Lee, Shiyi Lee, Yuyan Su, Susan Ling, Jeppe Dehli, Parmiss Khosravi, Colin Cotter, Keiko Ishida, Joy Collins, Siidartha Tamang, Wiam Abdalla Mohammed Madani, Johannes Kuosmanen, Josh Jenkins, Alison Hayward, Aaron Lopes, Joshua D. Bernstock, Michael Williams, Phillip J Sassene, Johannes Josef Fels, Kristian Kolind, Ulrik Lytt Rahbek, Stephen T. Buckley, Robert Langer, Giovanni Traverso. Effortless Adherence to Long-Term Obesity Treatment via automated Sequential Drug Releasing Intervals for Personalized Extended therapy (RIPE) in Large Animals. (under review: Nat. Chem. Eng)
  3. Jason Li*, Ceara Byrne*, Jia Y. Liang*, SeJun Lee, Mille Kronborg Lyhne, Anika Meng, Susan Rui Ling, Shiyi Li, Aaron Lopes, Parmiss Khosravi, Colin Cotter, Johannes Josef Fels, Jacob W. Coffey, Alison Hayward, Andreas Vegge, Ulrik Rahbek, Stephen T. Buckley, Robert Langer, Giovanni Traverso. Kinetics of Hypoglycemia in Diabetes Patients Informs Development of New Modes of Glucagon Therapy. (under review: Nat. Comm.)
  4. Binbin Ying, Kewang Nan, Qing Zhu, Tom Khuu, Hana Ro, Sophia Qin, Shubing Wang, Karen Jiang, Yonglin Chen, Guangyu Bao, Josh Jenkins, Andrew Pettinari, Johannes Kuosmanen, Keiko Ishida, Niora Fabian, Aaron Lopes, Flavia Codreanu, Joshua Morimoto, Jason Li, Alison Hayward, Robert Langer, Giovanni Traverso. An electroadhesive hydrogel interface prolongs porcine gastrointestinal mucosal theranostics. Sci. Trans. Med. 2025, 17(787), eadq1975
  5. Vivian R. Feig*, Sanghyun Park*, Pier Giuseppe Rivano*, Jinhee Kim, Benjamin Muller, Ashka Patel, Caroline Dial, Sofia Gonzalez, Hannah Carlisle, Flavia Codreanu, Aaron Lopes, Ayten E. Erdogan, Niora Fabian, Ashley Guevara, Andrew Pettinari, Jason Li, Jia Liang, Mark W. Tibbitt, Giovanni Traverso. Self-assembling Long-acting Injectable Microcrystals (SLIM). Nat. Chem. Eng. 2025 (in press)
  6. Stacie K. Totsch, Andrew Ishizuka, Kyung-Don Kang, Sam E. Gary, Abbey Rocco, Aaron E Fan, Pablo Valdes, SeungHo Lee, Jason Li, Luca Peruzzotti-Jametti, Sarah Blitz, Christopher M Garliss, James M. Johnston, James M. Markert, Geoffery Lynn, Joshua D. Bernstock, Li Zhou, and Gregory K. Friedman. Combination immunotherapy with vaccine and oncolytic HSV virotherapy is time dependent. Mol. Cancer Ther. 2024, doi: 10.1158/1535-7163
  7. Hen-Wei Huang, Peter R Chai, Seungho Lee, Tom Kerssemakers, Ali Imani, Jack Chen, Marco Heim, Jessica Y Bo, Adam Wentworth, Fokion T Sanoudos-Dramaliotis, Ian Ballinger, Saurav Maji, Matt Murphy, Alexander Alexiev, Gloria H Kang, Niora Fabian, Josh Jenkins, Andrew Pettinari, Keiko Ishida, Jason Li, Siheng Sean You, Alison M Hayward, Anantha Chandrakasan, Giovanni Traverso. An implantable system for opioid safety. Device 2024, 2(10): 100517.
  8. Alexander G. Yearley, Ruchit V. Patel, Sarah E. Blitz, Sarah Park, Alexander M. Madinger, Jason Li, Benjamin R. Johnston, Pier Paolo Peruzzi, SeungHo Lee, Shriya S. Srinivasan, Joshua D. Bernstock. Implantable Microdevices for Treating Brain Tumors. Device 2023, 1(4): 100068.
  9. Arrick G*, Sticker D*, Ghazal A*, Lu Y, Duncombe T, Gwynne D, Mouridsen B, Wainer J, Jepsen JPH, Last TS, Schultz D, Hess-Jimenez K, Alba EMD, Min S, Poulsen M, Anker C, Karandikar P, Pedersen HD, Collins J, Egecioglu NE, Tamang S, Cleveland C, Ishida K, Uhrenfeldt AH, Kuosmanen J, Pereverzina M, Hayward A, Kirk RK, You S, Dalsgaard CM, Gunnarsson SB, Bohr A, Azzarello A, Frederiksen MR, Herskind P, Li J, Roxhed N, Rahbek UL, Water JJ, Buckley ST, Traverso G. Cephalopod-inspired ingestible jetting devices for drug delivery. Nature 2024, 636, 481-487.
  10. Wei Chen, Jacob Wainer, Si Won Ryoo, Xiaoyue Qi, Rong Chang, Jason Li, Seung Ho Lee, Seokkee Min, Adam Wentworth, Joy E. Collins, Siddartha Tamang, Keiko Ishida, Alison Hayward, Robert Langer, Giovanni Traverso. Dynamic omnidirectional adhesive microneedle system for oral macromolecular drug delivery. Sci. Adv. 2022, eabk1792.
  11. Hen-Wei Huang, Siheng Sean You, Luca Di Tizio, Canchen Li, Erin Raftery, Claas Ehmke, Christoph Steiger, Junwei Li, Adam Wentworth, Ian Ballinger, Declan Gwynne, Kewang Nan, Jia Y Liang, Jason Li, James D Byrne, Joy Collins, Siddartha Tamang, Keiko Ishida, Florencia Halperin, Giovanni Traverso. An automated all-in-one system for carbohydrate tracking, glucose monitoring, and insulin delivery. J Control Release. 2022, 343:31-42
  12. Jason Li, Jia Y. Liang, Steven J. Laken, Robert Langer, Giovanni Traverso. Clinical opportunities for continuous biosensing and closed-loop therapies. Trends Chem. 2020, 2(4), 319-340.
  13. Amin GhavamiNejad*, Jason Li*, Brian Lu*, Liwei Zhou, Loretta Lam, Adria Giacca, Xiao Yu Wu. Glucose-Responsive Composite Microneedle Patch for Hypoglycemia-Triggered Delivery of Native Glucagon. Adv. Mater. 2019, 31(30), e1901051
  14. Mohammad Ali Amini*, Azhar Z Abbasi*, Ping Cai*, HoYin Lip, Claudia R Gordijo, Jason Li, Branson Chen, Li Zhang, Andrew M Rauth, Xiao Yu Wu. Combining tumor microenvironment modulating nanoparticles with doxorubicin to enhance chemotherapeutic efficacy and boost antitumor immunity. J. Natl. Cancer Inst. 2019 4(111), 399-408.
  15. Chunsheng He*, Jason Li*, Ping Cai*, Taksim Ahmed, Jeffrey T Henderson, Warren D Foltz, Reina Bendayan, Andrew Michael Rauth, Xiao Yu Wu. Two-Step Targeted Hybrid Nanoconstructs Increase Brain Penetration and Efficacy of the Therapeutic Antibody Trastuzumab against Brain Metastasis of HER2-Positive Breast Cancer. Adv. Funct. Mater. 2018, 28, 1705668.
  16. Jason Li, Michael K. L. Chu, Brian Lu, S. Mirzaie, Kuan Chen, Claudia R. Gordijo, Oliver Plettenburg, Adria Giacca, Xiao Yu Wu. Enhancing thermal stability of highly concentrated insulin formulation with Pluronic F-127 for long-term use in Microfabricated implantable devices: a combined experimental and computational study. Drug Deliv. Transl. Res. 2017, 7(4), 529-543.
  17. Chunsheng He*, Ping Cai*, Jason Li*, Tian Zhang, Lucy Lin, Azhar Z. Abbasi, Jeffrey T. Henderson, Andrew Michael Rauth, Xiao Yu Wu. Blood-brain barrier-penetrating amphiphilic polymer nanoparticles deliver docetaxel for the treatment of brain metastases of triple negative breast cancer. J. Control. Release 2017, 246, 98–109.
  18. Jason Li, Michael K. L. Chu, Claudia R. Gordijo, Azhar Z. Abbasi, Kuan Chen, Hibret A. Adissu, Matthias Lohn, Adria Giacca, Oliver Plettenburg, Xiao Yu Wu. Microfabricated microporous membranes reduce the host immune response and prolong the functional lifetime of a closed-loop insulin delivery implant in a type 1 diabetic rat model. Biomaterials 2015, 47, 51–60.
  19. Jason Li*, Ping Cai*, Alireza Shalviri*, Jeffrey T. Henderson, Chunsheng He, Warren D. Foltz, Preethy Prasad, Peter M. Brodersen, Yonghong Chen, Ralph DaCosta, Andrew M. Rauth, Xiao Yu Wu. A multifunctional polymeric nanotheranostic system delivers doxorubicin and imaging agents across the blood–brain barrier targeting brain metastases of breast cancer. ACS Nano 2014, 8(10), 9925–9940.
  20. Jason Li, Emily Rose, Daniel Frances, Yu Sun, Lidan You. Effect of oscillating fluid flow stimulation on osteocyte mRNA expression. J. Biomechanics 2012, 45(2), 247–251.
  21. Yan Liang Zhang*, Jason Li*, Steve To, Yong Zhang, Xutao Ye, Lidan You, Yu Sun. Automated nanomanipulation for nanodevice construction. Nanotechnology 2012, 23(6), 065304.
  22. Jason Li*, Yan Liang Zhang*, Steve To, Lidan You, Yu Sun. Effect of nanowire number, diameter, and doping density on Nano-FET biosensor sensitivity. ACS Nano 2011, 5(8), 6661–6668.
  23. Mohammad Ali Amini, Azhar Z Abbasi, Ping Cai, HoYin Lip, Claudia R Gordijo, Jason Li, Branson Chen, Li Zhang, Andrew M Rauth, Xiao Yu Wu. Combining Tumor Microenvironment Modulating Nanoparticles with Doxorubicin to Enhance Chemotherapeutic Efficacy and Boost Antitumor Immunity. J. Natl. Cancer Inst. 2019, 111(4), 399-408.
  24. Rui Xue Zhang, Jason Li, Tian Zhang, Mohammad A Amini, Chunsheng He, Brian Lu, Taksim Ahmed, Hoyin Lip, Andrew M Rauth, Xiao Yu Wu. Importance of integrating nanotechnology with pharmacology and physiology for innovative drug delivery and therapy-an illustration with firsthand examples. Acta Pharmacol Sin 2018, 9, 825-844.
  25. Kuan Chen, Hao Han R Chang, Alireza Shalviri, Jason Li, Jamie Anne Lugtu-Pe, Anil Kane, Xiao Yu Wu. Investigation of a new pH-responsive nanoparticulate pore former for controlled release enteric coating with improved processability and stability. Eur. J. Pharm. Biopharm. 2017, 120, 116–125.
  26. Rui Xue Zhang*, Lily Yi Li*, Jason Li, Zhensong Xu, Azhar Z Abbasi, Lucy Lin, Mohammad A Amini, Wei Yu Weng, Yu Sun, Andrew M Rauth, Xiao Yu Wu. Coordinating biointeraction and bioreaction of a nanocarrier material and an anticancer drug to overcome membrane rigidity and target mitochondria in multidrug-resistant cancer cells. Adv. Funct. Mater. 2017, 27(13), 1700804.
  27. Rui Xue Zhang, Ping Cai, Tian Zhang, King Chen, Jason Li, Ji Cheng, K Sandy Pang, Hibret A Adissu, Andrew M Rauth, Xiao Yu Wu. Polymer–lipid hybrid nanoparticles synchronize pharmacokinetics of co-encapsulated doxorubicin–mitomycin C and enable their spatiotemporal co-delivery and local bioavailability in breast tumor. Nanomed-nanotechnol. 2016, 12(5), 1279-1290.
  28. Rui Xue Zhang, Taksim Ahmed, Lily Yi Li, Jason Li, Azhar Z. Abbasi, Xiao Yu Wu. Design of nanocarriers for nanoscale drug delivery to enhance cancer treatment using hybrid polymer and lipid building blocks. Nanoscale 2017, 9, 1334–1355.
  29. Rui Xue Zhang, Ping Cai, Tian Zhang, King Chen, Jason Li, Ji Cheng, Sandy K. Pang, Hibret A. Adissu, Andrew M. Rauth, Xiao Yu Wu. Polymer–lipid hybrid nanoparticles synchronize pharmacokinetics of co-encapsulated doxorubicin–mitomycin C and enable their spatiotemporal co-delivery and local bioavailability in breast tumor. Nanomedicine 2016, 12(5), 1279–1290.
  30. Michael K. L. Chu, Claudia R. Gordijo, Jason Li, Azhar Z. Abbasi, Adria Giacca, Oliver Plettenburg, Xiao Yu Wu. In vivo performance and biocompatibility of a subcutaneous implant for real-time glucose-responsive insulin delivery. Diabetes Technol. Ther. 2015, 17(4), 255–267.
  31. Dan Shan, Jason Li, Ping Cai, Preethy Prasad, Franky Liu, Andrew M. Rauth, Xiao Yu Wu. RGD-conjugated solid lipid nanoparticles inhibit adhesion and invasion of αvβ3 integrin-overexpressing breast cancer cells. Drug Deliv. Transl. Res. 2015, 5(1), 15–26.

  32. Kathleen Denbeigh, Ali Vahit Esensoy, Penny Kinnear, Jason Li, Wilson Ma, Michelle MacArthur, Asmaa Maloul, Mario Milicevic, Aaron H. Persad, Farzan Sasangohar, Deborah Tihanyi, Liang (Leon) Yuan. Engineers teaching engineering communication: Integrating disciplinary expertise into the engineering communication curriculum. Proc. 2012 Canadian Engineering Education Association (CEEA12) Conference. Winnipeg, Manitoba, Canada, June 2012.

  33. Jian Chen, Jason Li, Yu Sun. Microfluidic approaches for cancer cell detection, characterization, and separation. Lab Chip 2012, 12, 1753–1767.

  34. Esther Lau, David W. Lee, Jason Li, John E. Davies, Qianhong Wu, Liyun Wang, Lidan You. Effect of low-magnitude, high-frequency vibration on the osteogenic differentiation of rat mesenchymal stromal cells. J. Orthopaedic Res. 2011, 29(7), 1075–1080.

  35. Jian Chen*, Yi Zheng*, Qingyuan Tan, Yan Liang Zhang, Jason Li, William R. Geddie, Michael A. S. Jewett, Yu Sun. A microfluidic device for simultaneous electrical and mechanical measurements on single cells. Biomicrofluidics 2011, 5(1), 014113.

  36. Jian Chen, Yi Zheng, Qingyuan Tan, Ehsan Shojaei-Baghini, Yan Liang Zhang, Jason Li, Preethy Prasad, Lidan You, Xiao Yu Wu, Yu Sun. Classification of cell types using a microfluidic device for mechanical and electrical measurement on single cells. Lab Chip 2011, 11, 3174–3181.

Selected Patents

Issued Patents
  1. M.S. Williams, J. Li, J. Coffey, C.W.J. Steigar, M. Jimenez, R.S. Langer, E.C. Salvador, A. Abramson, C.G. Traverso. Single or Multi-Dose Delivery Platform for Veterinary Applications. US 11,318,293-B2. Issued 2022-05-03.
  2. X.Y. Wu, K. Zhang, H. Huang, C. Gordijo, J.S.W. Li, M.K.L Chu. Implantable-Glucose-Responsive Insulin Delivery Device. US 9,387,279-B2. Issued 2016-07-12.
  3. X.Y. Wu, J. Li, A. G. Nejad, B. Lu, A. Giacca. Composition and Device for Preventing Hypoglycemia and Use Thereof. US 12,447,133-B2. Issued 2025-10-21.
Published Patent Applications
  1. C.G. Traverso, J. Li, S. Yang. Ingestible Chemical Energy Harvesting System with Extended Lifetime. US 2025/0064318-A1. Published 2025-02-27.
  2. J. Li, M.K.L. Chu, C. Gordijo, X.Y. Wu. Implantable-Glucose Responsive Insulin Delivery Device. US 2014/023963-A1. Published 2014-07-31.
  3. X.Y. Wu, K.H. Chen, H.H. Chang, A. Shalviri, J.S.W. Li. Tunable Polymeric Composite Coating for Controlled Release. US 2018/0133162-A1. Published 2018-05-17
  4. C.G. Traverso, J.S.W. Li, R. Langer. Readily Soluble and Thermostable Glucagon Formulations and Delivery for Mini-Dosing and Closed-Loop Prophylactic Treatment of Hypoglycemia. WO 2025/024243 PCT/US2024/038628. Published 2025-01-23.